Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys
Identifieur interne : 002339 ( Main/Exploration ); précédent : 002338; suivant : 002340Dysfunction of the subthalamic nucleus induces behavioral and movement disorders in monkeys
Auteurs : Carine Karachi [France] ; David Grabli [France] ; Nicolas Baup [France] ; Stéphanie Mounayar [France] ; Dominique Tandé [France] ; Chantal François [France] ; Etienne C. Hirsch [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-06-15.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Singe.
English descriptors
- KwdEn :
- Animal, Animals, Behavior, Animal (drug effects), Behavioral disorder, Bicuculline (adverse effects), Cercopithecus aethiops, Disease Models, Animal, Dysfunction, Functional Laterality (drug effects), GABA Agents (adverse effects), Globus Pallidus (drug effects), Globus Pallidus (physiology), Male, Microinjection, Microinjections (methods), Monkey, Movement Disorders (etiology), Movement Disorders (pathology), Muscimol (adverse effects), Nervous system diseases, Reaction Time (drug effects), Stereotyped Behavior (drug effects), Stereotyped Behavior (physiology), Stereotypy, Subthalamic Nucleus (drug effects), Subthalamic Nucleus (physiopathology), Subthalamic nucleus, hemiballism, microinjections, monkeys, stereotypies, subthalamic nucleus.
- MESH :
- chemical , adverse effects : Bicuculline, GABA Agents, Muscimol.
- drug effects : Behavior, Animal, Functional Laterality, Globus Pallidus, Reaction Time, Stereotyped Behavior, Subthalamic Nucleus.
- etiology : Movement Disorders.
- methods : Microinjections.
- pathology : Movement Disorders.
- physiology : Globus Pallidus, Stereotyped Behavior.
- physiopathology : Subthalamic Nucleus.
- Animals, Cercopithecus aethiops, Disease Models, Animal, Male.
Abstract
High‐frequency stimulation of the subthalamic nucleus (STN) in parkinsonian patients is reported to induce psychiatric effects. The likely explanation for these effects is the partitioning of the STN into sensorimotor, associative, and limbic anatomo‐functional territories. Thus, a specific neuronal dysfunction of the STN sensorimotor territory could lead to abnormal movements, whereas a dysfunction of the associative or limbic territory could lead to behavioral disturbances. To test this hypothesis, neuronal dysfunction of the STN was induced by microinjections of the GABA agonist muscimol, or antagonist bicucculline, in various parts of the nucleus in three monkeys. Stereotyped behaviors (licking and biting fingers) and/or violent hyperactivity were obtained with bicuculline injected into the anteromedial, associative, and limbic territories, whereas injections of muscimol induced no major effects. Abnormal limb movements (contralateral ballism) were obtained after muscimol or bicuculline injections into the posterolateral, sensorimotor territory. Control injections localized around the STN induced other effects (mainly torticollis), which underlines the specificity of STN injection effects. Our study supports the hypothesis that the anteromedial part of the STN is involved in behavioral control. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22547
Affiliations:
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The likely explanation for these effects is the partitioning of the STN into sensorimotor, associative, and limbic anatomo‐functional territories. Thus, a specific neuronal dysfunction of the STN sensorimotor territory could lead to abnormal movements, whereas a dysfunction of the associative or limbic territory could lead to behavioral disturbances. To test this hypothesis, neuronal dysfunction of the STN was induced by microinjections of the GABA agonist muscimol, or antagonist bicucculline, in various parts of the nucleus in three monkeys. Stereotyped behaviors (licking and biting fingers) and/or violent hyperactivity were obtained with bicuculline injected into the anteromedial, associative, and limbic territories, whereas injections of muscimol induced no major effects. Abnormal limb movements (contralateral ballism) were obtained after muscimol or bicuculline injections into the posterolateral, sensorimotor territory. Control injections localized around the STN induced other effects (mainly torticollis), which underlines the specificity of STN injection effects. Our study supports the hypothesis that the anteromedial part of the STN is involved in behavioral control. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name></noRegion><name sortKey="Baup, Nicolas" sort="Baup, Nicolas" uniqKey="Baup N" first="Nicolas" last="Baup">Nicolas Baup</name><name sortKey="Baup, Nicolas" sort="Baup, Nicolas" uniqKey="Baup N" first="Nicolas" last="Baup">Nicolas Baup</name><name sortKey="Baup, Nicolas" sort="Baup, Nicolas" uniqKey="Baup N" first="Nicolas" last="Baup">Nicolas Baup</name><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name><name sortKey="Grabli, David" sort="Grabli, David" uniqKey="Grabli D" first="David" last="Grabli">David Grabli</name><name sortKey="Grabli, David" sort="Grabli, David" uniqKey="Grabli D" first="David" last="Grabli">David Grabli</name><name sortKey="Grabli, David" sort="Grabli, David" uniqKey="Grabli D" first="David" last="Grabli">David Grabli</name><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name><name sortKey="Mounayar, Stephanie" sort="Mounayar, Stephanie" uniqKey="Mounayar S" first="Stéphanie" last="Mounayar">Stéphanie Mounayar</name><name sortKey="Mounayar, Stephanie" sort="Mounayar, Stephanie" uniqKey="Mounayar S" first="Stéphanie" last="Mounayar">Stéphanie Mounayar</name><name sortKey="Tande, Dominique" sort="Tande, Dominique" uniqKey="Tande D" first="Dominique" last="Tandé">Dominique Tandé</name><name sortKey="Tande, Dominique" sort="Tande, Dominique" uniqKey="Tande D" first="Dominique" last="Tandé">Dominique Tandé</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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